Suppression of Allograft Rejection by Tim-1-Fc through Cross-Linking with a Novel Tim-1 Binding Partner on T Cells
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چکیده
منابع مشابه
Suppression of Allograft Rejection by Tim-1-Fc through Cross-Linking with a Novel Tim-1 Binding Partner on T Cells
Engagement of T-cell immunoglobulin mucin (Tim)-1 on T cells with its ligand, Tim-4, on antigen presenting cells delivers positive costimulatory signals to T cells. However, the molecular mechanisms for Tim-1-mediated regulation of T-cell activation and differentiation are relatively poorly understood. Here we investigated the role of Tim-1 in T-cell responses and allograft rejection using reco...
متن کاملAllograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs.
Tregs play a pivotal role in inducing and maintaining donor-specific transplant tolerance. The T cell immunoglobulin and mucin domain-3 protein (TIM-3) is expressed on many fully activated effector T cells. Along with program death 1 (PD-1), TIM-3 is used as a marker for exhausted effector T cells, and interaction with its ligand, galectin-9, leads to selective death of TIM-3+ cells. We report ...
متن کاملTIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells Short title: Role of TIM-1 and TIM-3 in mast cell function
Members of the T cell immunoglobulinand mucin-domain-containing molecule (TIM) family have roles in T cell-mediated immune responses. TIM-1 and TIM-2 are predominantly expressed on Th2 cells, whereas TIM-3 is preferentially expressed on Th1 and Th17 cells. We found that TIM-1 and TIM-3, but neither TIM-2 nor TIM-4, were constitutively expressed on mouse peritoneal mast cells and bone-marrow-der...
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Polymorphisms in the T cell (or transmembrane) immunoglobulin and mucin ( ) gene, particularly in the mucin domain, have been associated domain 1 TIM-1 with atopy and allergic diseases in mice and human. Geneticand antibody-mediated studies revealed that Tim-1 functions as a positive regulator of Th2 responses, while certain antibodies to Tim-1 can exacerbate or reduce allergic lung inflammatio...
متن کاملKim-1/Tim-1 and Immune cells: Shifting Sands
Kim-1/Tim-1 is an apoptotic-cell phagocytosis and scavenger receptor that is most highly upregulated in proximal tubular epithelium in acute and chronic kidney injury. While Kim-1/Tim-1 has been proposed to be a costimulatory molecule for immune cells, its potential immunological role has been controversial. In the presence of very high epithelial cell expression, understanding the influence of...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0021697